Recombinant Human METTL14 protein (ab163640)

Overview

  • Product name
    Recombinant Human METTL14 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRET CRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIY KDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLR ELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYR ETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRK WGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRST DGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRD STIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSP PPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHR GGFPPR
    • Amino acids
      1 to 456
    • Tags
      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • KIAA1627
    • MET14_HUMAN
    • Methyltransferase like 14
    • Methyltransferase-like protein 14
    • METTL14
    • N6-adenosine-methyltransferase subunit METTL14
    • OTTHUMP00000219837
    see all
  • Function
    N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing and mRNA stability (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop. M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization.
  • Sequence similarities
    Belongs to the MT-A70-like family.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • ab163640 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163640 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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