UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IV
UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IVb
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis.
Widely expressed. Strongly overexpressed in pancreatic cancer.