The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab113156 was purified using conventional chromatography techniques.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.00 Constituents: 0.32% Tris HCl, 10% Glycerol
Cell growth inhibiting gene 36 protein
Cell growth-inhibiting gene 36 protein
GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX
Matrix Gla protein
FunctionAssociates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Involvement in diseaseDefects in MGP are the cause of Keutel syndrome (KS) [MIM:245150]. KS is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
Sequence similaritiesBelongs to the osteocalcin/matrix Gla protein family. Contains 1 Gla (gamma-carboxy-glutamate) domain.
Post-translational modificationsRequires vitamin K-dependent gamma-carboxylation for its function.