Recombinant Human MGP protein (denatured) (ab113156)

Overview

  • Product name
    Recombinant Human MGP protein (denatured)
    See all MGP proteins and peptides
  • Protein length
    Full length protein
  • Description
    Recombinant Human MGP protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMYESHESMESYELNPFINRRNANTFISPQQ RWRAKVQERIRERSKPVHELNREACDDYRLCERYAMVYGYNAAYNRYF
    • Molecular weight
      12 kDa including tags
    • Amino acids
      20 to 96
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab113156 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.
    ab113156 was purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names
    • Cell growth inhibiting gene 36 protein
    • Cell growth-inhibiting gene 36 protein
    • GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX
    • GIG36
    • Matrix Gla protein
    • MGLAP
    • MGP
    • MGP_HUMAN
    • NTI
    see all
  • Function
    Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
  • Involvement in disease
    Defects in MGP are the cause of Keutel syndrome (KS) [MIM:245150]. KS is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
  • Sequence similarities
    Belongs to the osteocalcin/matrix Gla protein family.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Post-translational
    modifications
    Requires vitamin K-dependent gamma-carboxylation for its function.
  • Cellular localization
    Secreted.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab113156 (3 µg) at approximately 11.8 kDa.

References

ab113156 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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