Overview

  • Product name
    Recombinant Human MMAB protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMQSRGPQGVEDGDRPQPSSKTPRIPKIYTK TGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALELVTEKGHTFA EELQKIQCTLQDVGSALATPCSSAREAHLKYTTFKAGPILELEQWIDKYT SQLPPLTAFILPSGGKISSALHFCRAVCRRAERRVVPLVQMGETDANVAK FLNRLSDYLFTLARYAAMKEGNQEKIYKKNDPSAESEGL
    • Molecular weight
      26 kDa including tags
    • Amino acids
      33 to 250
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab99217 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 95 % SDS-PAGE.
    ab99217 was purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 7.5

General Info

  • Alternative names
    • aquocob(I)alamin vitamin B12s adenosyltransferase
    • ATP:cob(I)alamin adenosyltransferase
    • ATP:corrinoid adenosyltransferase
    • ATR
    • c-diamide adenosyltransferase
    • cblB
    • Cob
    • Cob(I)alamin adenosyltransferase
    • Cob(I)yrinic acid a
    • cob(I)yrinic acid a c diamide adenosyltransferase mitochondrial
    • Methylmalonic aciduria (cobalamin deficiency) cblB type
    • Methylmalonic aciduria type B protein
    • MGC20496
    • mitochondrial
    • MMAB
    • MMAB gene
    • MMAB_HUMAN
    • OTTHUMP00000240563
    • OTTHUMP00000240564
    see all
  • Tissue specificity
    Expressed in liver and skeletal muscle.
  • Pathway
    Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.
  • Involvement in disease
    Defects in MMAB are the cause of methylmalonic aciduria type cblB (MMAB) [MIM:251110]; also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive.
  • Sequence similarities
    Belongs to the Cob(I)alamin adenosyltransferase family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3µg ab99217.

References

ab99217 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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