Overview

  • Product nameRecombinant Human MMP11 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab92861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

    Mass Spectrometry

  • Purity> 90 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 100mM Imidazole
    Constituents: 0.5M Sodium chloride, 20mM Tris HCl, 1mM Beta mercaptoethanol, pH 8.0

General Info

  • Alternative names
    • Matrix Metalloproteinase 11
    • Matrix metalloproteinase-11
    • MMP-11
    • Mmp11
    • MMP11_HUMAN
    • SL 3
    • SL-3
    • SL3
    • ST3
    • STMY3
    • Stromelysin 3
    • Stromelysin III
    • Stromelysin-3
    see all
  • FunctionMay play an important role in the progression of epithelial malignancies.
  • Tissue specificitySpecifically expressed in stromal cells of breast carcinomas.
  • Sequence similaritiesBelongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • DomainThe conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.
  • Information by UniProt

Recombinant Human MMP11 protein images

  • 10% SDS-PAGE stained with Coomassie Blue.

References for Recombinant Human MMP11 protein (ab92861)

This product has been referenced in:
  • Roscilli G  et al. Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. J Transl Med 12:54 (2014). Read more (PubMed: 24564996) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"