Overview

  • Product name
    Recombinant Human MMP11 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab92861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

    Mass Spectrometry

  • Purity
    > 90 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 100mM Imidazole
    Constituents: 0.5M Sodium chloride, 20mM Tris HCl, 1mM Beta mercaptoethanol, pH 8.0

General Info

  • Alternative names
    • Matrix Metalloproteinase 11
    • Matrix metalloproteinase-11
    • MMP-11
    • Mmp11
    • MMP11_HUMAN
    • SL 3
    • SL-3
    • SL3
    • ST3
    • STMY3
    • Stromelysin 3
    • Stromelysin III
    • Stromelysin-3
    see all
  • Function
    May play an important role in the progression of epithelial malignancies.
  • Tissue specificity
    Specifically expressed in stromal cells of breast carcinomas.
  • Sequence similarities
    Belongs to the peptidase M10A family.
    Contains 4 hemopexin-like domains.
  • Domain
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications
    The precursor is cleaved by a furin endopeptidase.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Images

  • 10% SDS-PAGE stained with Coomassie Blue.

References

This product has been referenced in:
  • Roscilli G  et al. Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. J Transl Med 12:54 (2014). Read more (PubMed: 24564996) »

See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab92861.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up