This product is an active protein and may elicit a biological response in vivo, handle with caution.
Matrix metallopeptidase 14 (membrane inserted)
Matrix metalloproteinase 14
Membrane type 1 matrix metalloproteinase
Membrane type 1 metalloprotease
Membrane type matrix metalloproteinase 1
Membrane-type matrix metalloproteinase 1
Membrane-type-1 matrix metalloproteinase
MT MMP 1
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7.
Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.
Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains.
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
The precursor is cleaved by a furin endopeptidase.
Membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.