Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV
    • Molecular weight
      48 kDa including tags
    • Amino acids
      1 to 407
    • Tags
      His tag N-Terminus
    • Additional sequence information
      MNDA Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 427 amino acids (1-407 a.a.) and having a molecular mass of 47.9 kDa.

Specifications

Our Abpromise guarantee covers the use of ab117166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.
    ab117166 is purified by proprietary chromatographic techniques.
  • Form
    Liquid
  • Additional notes
    Although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 10% Glycerol, 0.02% DTT, 0.32% Tris HCl

General Info

  • Alternative names
    • MNDA
    • MNDA_HUMAN
    • Myeloid cell nuclear differentiation antigen
    • OTTHUMP00000024384
    • PYHIN3
    see all
  • Function
    May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
  • Tissue specificity
    Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.
  • Sequence similarities
    Contains 1 DAPIN domain.
    Contains 1 HIN-200 domain.
  • Domain
    Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.
  • Cellular localization
    Nucleus. Cytoplasm. Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.
  • Information by UniProt

References for Recombinant Human MNDA protein (ab117166)

ab117166 has not yet been referenced specifically in any publications.

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