Overview

Description

  • NatureRecombinant
  • SourceSaccharomyces cerevisiae
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEG EDLNEW IAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWA DGTNIKKPIKCSAP KYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMS VAKTILKRLFRVYAHIYHQHFD SVMQLQEEAHLNTSFKHFIFFVQEFN LIDRRELAPLQELIEKLGSKDR

Specifications

Our Abpromise guarantee covers the use of ab88401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab88401 was purified using affinity chromatography.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5

General Info

  • Alternative names
    • B1, Mps One Binder kinase activator like 1B (yeast)
    • C2orf6
    • Chromosome 2 open reading frame 6
    • FLJ10788
    • FLJ11595
    • MATS1
    • MOB kinase activator 1A
    • MOB1
    • Mob1 alpha
    • Mob1 homolog 1B
    • MOB1 Mps One Binder homolog A
    • MOB1 Mps One Binder kinase activator like 1B
    • Mob1A
    • MOB4B
    • Mob4B protein
    • MOBK1B
    • Mobkl1b
    • MOL1B_HUMAN
    • Mps one binder kinase activator like 1B
    • Mps one binder kinase activator-like 1B
    • Protein Mob4B
    see all
  • FunctionActivator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.
  • Tissue specificityAdrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.
  • Sequence similaritiesBelongs to the MOB1/phocein family.
  • Information by UniProt

References for Recombinant Human MOBK1B protein (ab88401)

ab88401 has not yet been referenced specifically in any publications.

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