Recombinant Human MORC3 protein (Tagged) (ab225648)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Tags: His tag N-Terminus
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Human MORC3 protein (Tagged) -
Purity
> 90 % SDS-PAGE. -
Expression system
Escherichia coli -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQI WIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLY GNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAF NKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWN LRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYS LRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVY -
Predicted molecular weight
49 kDa including tags -
Amino acids
1 to 290 -
Tags
His tag N-Terminus -
Additional sequence information
N-terminal 6xHis-SUMO tag.
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab225648 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.2
Constituents: 50% Glycerol (glycerin, glycerine), Tris buffer
General Info
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Alternative names
- KIAA0136
- Microrchidia 3
- MORC family CW type zinc finger 3
see all -
Function
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). -
Tissue specificity
Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney. -
Sequence similarities
Contains 1 CW-type zinc finger. -
Post-translational
modificationsSumoylation is involved in interaction with PML and localization to PML nuclear bodies. -
Cellular localization
Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. - Information by UniProt
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab225648 has not yet been referenced specifically in any publications.