The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Class I histocompatibility antigen like protein
Class I histocompatibility antigen-like protein
Major histocompatibility complex class I like sequence
Major histocompatibility complex class I related
Major histocompatibility complex class I related gene protein
Major histocompatibility complex class I related isoform CRA a
Major histocompatibility complex class I related isoform CRA c
Major histocompatibility complex class I related isoform CRA d
Major histocompatibility complex class I-related gene protein
MHC class I like antigen MR 1
MHC class I like antigen MR1
MHC class I related gene protein
MHC class I related protein 1 isoform B
MHC class I related protein 1 isoform C
MHC class I-related gene protein
Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.
Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression. The alpha-3 region mediates interaction with B2M (PubMed:23051753). The ligand-binding groove is ideally suited to present small organic compounds that can originate from vitamins rather than antigenic peptides.
Secreted; Cell membrane. Endoplasmic reticulum and Cell membrane. Endoplasmic reticulum membrane. The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway.