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Product name Recombinant Human MRP2 protein
Protein length Protein fragment Description
Source Wheat germ
Amino Acid Sequence
Sequence LKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEK SSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKA
Molecular weight 37 kDa including tags
Amino acids 214 to 313
Tags GST tag N-Terminus Specifications
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activity useful for Antibody Production and Protein Array
Additional notes Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
Concentration information loading... Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced
ATP binding cassette sub family C (CFTR/MRP) member 2
Function Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Tissue specificity Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Involvement in disease Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
Sequence similarities Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.
Cellular localization Membrane.
Information by UniProt
Recombinant Human MRP2 protein images
References for Recombinant Human MRP2 protein (ab112272)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"