Nucleoside diphosphate linked moiety X type motif 1
Nucleoside diphosphate-linked moiety X motif 1
Nudix (nucleoside diphosphate linked moiety X) type motif 1
Nudix hydrolase 1
Nudix motif 1
Nudix type motif 1
FunctionAntimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
Tissue specificityWidely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
Sequence similaritiesBelongs to the Nudix hydrolase family. Contains 1 nudix hydrolase domain.
Developmental stageIn peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
Post-translational modificationsThe N-terminus is blocked.
Cellular localizationCytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.