This product is an active protein and may elicit a biological response in vivo, handle with caution.
E3 ubiquitin-protein ligase TRIM63
Iris RING finger protein
Muscle specific ring finger protein 1
Muscle specific ring finger protein 2
Muscle-specific RING finger protein 1
RING finger protein 28
Striated muscle RING zinc finger protein
Tripartite motif containing 63
tripartite motif containing 63, E3 ubiquitin protein ligase
Tripartite motif containing protein 63
Tripartite motif-containing protein 63
Ubiquitin ligase TRIM63
FunctionE3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Tissue specificityMuscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
PathwayProtein modification; protein ubiquitination.
Sequence similaritiesContains 1 B box-type zinc finger. Contains 1 COS domain. Contains 1 RING-type zinc finger.
Developmental stageExpressed throughout all developmental stages.
DomainThe RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity.
Cellular localizationCytoplasm. Nucleus. Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes.