Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      63 kDa
    • Amino acids
      519 to 869
    • Tags
      GST tag N-Terminus
    • Additional sequence information
      Recombinant fragment from human MUSK, cytoplasmic domain, amino acids 519-end.

Associated products

Specifications

Our Abpromise guarantee covers the use of ab71693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Specific activity is 6.7 nmol/min/mg.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form
    Liquid
  • Additional notes

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • CMS9
    • FADS
    • MDK 4
    • MDK4
    • MGC126323
    • MGC126324
    • Muscle
    • Muscle associated receptor tyrosine kinase
    • Muscle skeletal receptor tyrosine kinase
    • Muscle skeletal receptor tyrosine protein kinase
    • Muscle specific kinase receptor
    • Muscle specific tyrosine kinase receptor
    • Muscle specific tyrosine protein kinase receptor
    • Muscle-specific kinase receptor
    • Muscle-specific tyrosine-protein kinase receptor
    • MuSK
    • MUSK_HUMAN
    • Neural fold somite kinase 1
    • Neural fold somite kinase 2
    • Neural fold somite kinase 3
    • Neural fold somite kinase1
    • Neural fold somite kinase2
    • Neural fold somite kinase3
    • Nsk 1
    • Nsk 2
    • Nsk 3
    • Nsk1
    • Nsk2
    • Nsk3
    • Receptor tyrosine kinase MuSK
    • Skeletal muscle receptor tyrosine kinase
    • skeletal receptor tyrosine-protein kinase
    see all
  • Function
    Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.
  • Involvement in disease
    Defects in MUSK is a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD) [MIM:608931]. A post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance. Note=MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 FZ (frizzled) domain.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

References

ab71693 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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