Recombinant Human MYO15A protein (ab162441)

Overview

  • Product name
    Recombinant Human MYO15A protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      PCILAINHNGLNFLSTETHELMVKFPLKEIQSTRTQRPTANSSYPYVEIA LGDVAAQRTLQLQLEQGLELCRVVAVHVENLLSAHEKRLTLPPSEITLL
    • Amino acids
      3432 to 3530
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab162441 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • DFNB3
    • MYO15
    • MYO15_HUMAN
    • MYO15A
    • Myosin XV
    • Myosin XVA
    • Unconventional myosin 15
    • Unconventional myosin XV
    • Unconventional myosin-15
    • Unconventional myosin-XV
    see all
  • Function
    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles.
  • Tissue specificity
    Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells.
  • Involvement in disease
    Defects in MYO15A are the cause of deafness autosomal recessive type 3 (DFNB3) [MIM:600316]. DFNB3 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • Sequence similarities
    Contains 1 FERM domain.
    Contains 3 IQ domains.
    Contains 1 myosin head-like domain.
    Contains 2 MyTH4 domains.
    Contains 1 SH3 domain.
  • Cellular localization
    Cell projection > stereocilium. Cytoplasm > cytoskeleton. Localizes to stereocilium tips in cochlear and vestibular hair cells.
  • Information by UniProt

Images

  • ab162441 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab162441 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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