Recombinant human Myostatin Propeptide protein (ab49855)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionO14793
    • SpeciesHuman
    • SequenceMNENSEQKEN VEKEGLCNAC TWRQNTKSSR IEAIKIQILS KLRLETAPNI SKDVIRQLLP KAPPLRELID QYDVQRDDSS DGSLEDDDYH ATTETIITMP TESDFLMQVD GKPKCCFFKF SSKIQYNKVV KAQLWIYLRP VETPTTVFVQ ILRLIKPMKD GTRYTGIRSL KLDMNPGTGI WQSIDVKTVL QNWLKQPESN LGIEIKALDE NGHDLAVTFP GPGEDGLNPF LEVKVTDTPK RSRR
    • Molecular weight28 kDa
    • Amino acids23 to 266

Specifications

Our Abpromise guarantee covers the use of ab49855 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Determined by its ability to neutralize the Myostatin inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.01–0.04 μg/ml in the presence of 50 ng/ml Myostatin.

  • Applications

    SDS-PAGE

  • Endotoxin level< 0.100 Eu/µg
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • Cmpt
    • GDF-8
    • GDF8_HUMAN
    • Growth/differentiation factor 8
    • MSLHP
    • MSTN
    • MSTN myostatin
    • Myostatin
    • Myostatin Propeptide
    see all
  • FunctionActs specifically as a negative regulator of skeletal muscle growth.
  • Involvement in diseaseDefects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong.
  • Sequence similaritiesBelongs to the TGF-beta family.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant human Myostatin Propeptide protein (ab49855)

ab49855 has not yet been referenced specifically in any publications.

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