Recombinant Human NADH dehydrogenase subunit 4 protein (ab116897)

Overview

  • Product nameRecombinant Human NADH dehydrogenase subunit 4 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP03905
    • SpeciesHuman
    • SequenceYSLYIFTTTQWGSLTHHINNIKPSFTRENTLMFIHLSPILLLSLNPDIIT GFSS
    • Molecular weight32 kDa including tags
    • Amino acids406 to 459

Specifications

Our Abpromise guarantee covers the use of ab116897 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    ELISA

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • MT-ND4
    • MTND4
    • NADH dehydrogenase subunit 4
    • NADH-ubiquinone oxidoreductase chain 4
    • NADH4
    • ND4
    • NU4M_HUMAN
    see all
  • FunctionCore subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
  • Involvement in diseaseDefects in MT-ND4 are a cause of Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.
    Defects in MT-ND4 are a cause of Leber hereditary optic neuropathy with dystonia (LDYT) [MIM:500001]; also called familial dystonia with visual failure and striatal lucencies. LDYT is part of a spectrum of Leber hereditary optic neuropathy. It is characterized by the association of optic atrophy and central vision loss with dystonia.
    Defects in MT-ND4 are a cause of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS) [MIM:540000]. MELAS is a genetically heterogenious disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness.
  • Sequence similaritiesBelongs to the complex I subunit 4 family.
  • Cellular localizationMitochondrion membrane.
  • Information by UniProt

Recombinant Human NADH dehydrogenase subunit 4 protein images

  • 12.5% SDS-PAGE showing ab116897 at approximately 31.57kDa and stained with Coomassie Blue.

References for Recombinant Human NADH dehydrogenase subunit 4 protein (ab116897)

ab116897 has not yet been referenced specifically in any publications.

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As I understand from your email, you were looking for an antibody against NADH dehydrogenase?

ab116897 is not an antibody but a protein expressed from wheat germ. The protein is a recombinant fragment of...

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