Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step.
Isoform 2 may be brain-specific.
Protein modification; protein glycosylation.
Contains 1 EGF-like domain.
The tyrosine-based internalization signal may be essential for its retrieval from the plasma membrane to the TGN. The C-terminal NPFKD sequence is an attractive candidate for either an endocytosis signal acting at the plasma membrane or a retrieval signal acting at the TGN to return the enzyme to the cis/medial-Golgi.