The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 µg/µl. Best use within three months from the date of receipt of this protein.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
hNa6/Scn8a voltage gated sodium channel
Motor endplate disease
peripheral nerve protein type 4
Sodium channel protein type 8 alpha subunit
Sodium channel protein type 8 subunit alpha
Sodium channel protein type VIII alpha subunit
Sodium channel protein type VIII subunit alpha
Sodium channel voltage gated type VIII alpha
Sodium channel voltage gated type VIII alpha polypeptide
Sodium channel voltage gated type VIII alpha subunit
Voltage gated sodium channel subunit alpha Nav1.6
Voltage-gated sodium channel subunit alpha Nav1.6
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.
Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages.
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily. Contains 1 IQ domain.
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
May be ubiquitinated by NEDD4L; which would promote its endocytosis.
Membrane and Cytoplasmic vesicle. Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.