Recombinant Human Nav1.7 protein (ab114304)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionQ15858
    • SpeciesHuman
    • SequenceGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFS TDSGQCPEGYTCVKIGRNPDY
    • Molecular weight33 kDa including tags
    • Amino acids269 to 339

Specifications

Our Abpromise guarantee covers the use of ab114304 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05µg/µl
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • ETHA
    • GEFSP7
    • hNE Na
    • hNE-Na
    • hNENa
    • NE NA
    • NENA
    • Neuroendocrine sodium channel
    • Peripheral sodium channel 1
    • PN1
    • Scn9a
    • SCN9A_HUMAN
    • Sodium channel protein type 9 subunit alpha
    • Sodium channel protein type IX subunit alpha
    • Sodium channel voltage gated type IX alpha
    • Sodium channel voltage gated type IX alpha polypeptide
    • Sodium channel voltage gated type IX alpha subunit
    • Voltage gated sodium channel alpha subunit Nav1.7
    • Voltage gated sodium channel subunit alpha Nav1
    • Voltage-gated sodium channel subunit alpha Nav1.7
    see all
  • FunctionMediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:7720699, PubMed:17167479, PubMed:25240195, PubMed:26680203, PubMed:15385606, PubMed:16988069, PubMed:17145499, PubMed:19369487, PubMed:24311784). It is a tetrodotoxin-sensitive Na(+) channel isoform (PubMed:7720699). Plays a role in pain mechanisms, especially in the development of inflammatory pain (PubMed:17167479, PubMed:17145499, PubMed:19369487, PubMed:24311784).
  • Tissue specificityExpressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion.
  • Involvement in diseasePrimary erythermalgia
    Indifference to pain, congenital, autosomal recessive
    Paroxysmal extreme pain disorder
    Generalized epilepsy with febrile seizures plus 7
    Febrile seizures, familial, 3B
  • Sequence similaritiesBelongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily.
    Contains 1 IQ domain.
  • DomainThe sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
  • Post-translational
    modifications
    Phosphorylation at Ser-1490 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents.
    Ubiquitinated by NEDD4L; which may promote its endocytosis. Does not seem to be ubiquitinated by NEDD4.
  • Cellular localizationCell membrane. Cell projection. In neurite terminals.
  • Information by UniProt

Recombinant Human Nav1.7 protein images

  • 12.5% SDS-PAGE image showing ab114304 Stained with Coomassie Blue.

References for Recombinant Human Nav1.7 protein (ab114304)

ab114304 has not yet been referenced specifically in any publications.

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