This product is an active protein and may elicit a biological response in vivo, handle with caution.
Differentiation related gene1 protein
Differentiation-related gene 1 protein
Human mRNA for RTP complete cds
N myc downstream regulated gene 1
N myc downstream regulated gene 1 protein
N-myc downstream-regulated gene 1 protein
Nickel specific induction protein
Nickel specific induction protein Cap43
Nickel-specific induction protein Cap43
Nmyc downstream regulated
Nmyc downstream regulated gene1
Nmyc downstream regulated gene1 protein
Protein regulated by oxygen 1
Protein regulated by oxygen1
Reduced in tumor
Reducing agents and tunicamycin responsive protein
Reducing agents and tunicamycin-responsive protein
Tunicamycin responsive protein
FunctionMay have a growth inhibitory role.
Tissue specificityUbiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.
Involvement in diseaseDefects in NDRG1 are the cause of Charcot-Marie-Tooth disease type 4D (CMT4D) [MIM:601455]; also known as hereditary motor and sensory neuropathy Lom type (HMSNL). CMT4D is a recessive form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
Sequence similaritiesBelongs to the NDRG family.
Cellular localizationCytoplasm. Nucleus. Cell membrane. Whereas in prostate epithelium and placental chorion it is located in both the cytoplasm and the nucleus, nuclear staining is not observed in colon epithelium cells. Instead its localization changes from the cytoplasm to the plasma membrane during differentiation of colon carcinoma cell lines in vitro.