Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMAQDQTQDTQ LITVDEKLDI TTLTGVPEEH IKTRKVRIFV PARNNMQSGV NNTKKWKMEF DTRERWENPL MGWASTADPL SNMVLTFSTK EDAVSFAEKN GWSYDIEERK VPKPKSKSYG ANFSWNKRTR VSTK

Associated products

Specifications

Our Abpromise guarantee covers the use of ab86684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab86684 is purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 20mM Tris HCl, pH 8.0

General Info

  • Alternative names
    • AQDQ
    • CI 18
    • CI 18 kDa
    • CI AQDQ
    • CI-18 kDa
    • CI-AQDQ
    • Complex I 18 kDa
    • Complex I AQDQ
    • Complex I-18 kDa
    • Complex I-AQDQ
    • mitochondrial
    • mitochondrial respiratory chain complex I (18 KD subunit)
    • NADH coenzyme Q reductase
    • NADH dehydrogenase
    • NADH dehydrogenase (ubiquinone) Fe S protein 4 18kDa
    • NADH dehydrogenase [ubiquinone] iron-sulfur protein 4
    • NADH ubiquinone oxidoreductase 18 kDa subunit
    • NADH-ubiquinone oxidoreductase 18 kDa subunit
    • NDUFS4
    • NDUS4_HUMAN
    see all
  • FunctionAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
  • Involvement in diseaseDefects in NDUFS4 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.
  • Sequence similaritiesBelongs to the complex I NDUFS4 subunit family.
  • Cellular localizationMitochondrion inner membrane.
  • Information by UniProt

Recombinant Human Ndufs4 protein images

  • 15% SDS-PAGE showing ab86684(3µg).

References for Recombinant Human Ndufs4 protein (ab86684)

ab86684 has not yet been referenced specifically in any publications.

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