The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab86684 is purified using conventional chromatography techniques.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituents: 30% Glycerol, 20mM Tris HCl, pH 8.0
CI 18 kDa
Complex I 18 kDa
Complex I AQDQ
Complex I-18 kDa
mitochondrial respiratory chain complex I (18 KD subunit)
NADH coenzyme Q reductase
NADH dehydrogenase (ubiquinone) Fe S protein 4 18kDa
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4
NADH ubiquinone oxidoreductase 18 kDa subunit
NADH-ubiquinone oxidoreductase 18 kDa subunit
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Involvement in disease
Defects in NDUFS4 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.