Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      DVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKN KNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQD
    • Molecular weight
      37 kDa including tags
    • Amino acids
      976 to 1075

Specifications

Our Abpromise guarantee covers the use of ab116949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • DKFZp686D06121
    • DKFZp686K12169
    • kat
    • KIAA1901
    • MGC138800
    • MGC189817
    • NEK1
    • NEK1_HUMAN
    • Never in mitosis A-related kinase 1
    • Never in mitosis gene A-related kinase 1
    • NIMA (never in mitosis gene a)-related kinase 1
    • NIMA-related kinase 1
    • NimA-related protein kinase 1
    • NY-REN-55
    • OTTHUMP00000219432
    • OTTHUMP00000219433
    • OTTHUMP00000219434
    • OTTHUMP00000219435
    • Protein-serine/threonine kinase
    • Renal carcinoma antigen NY-REN-55
    • Serine/threonine-protein kinase Nek1
    • SRPS2
    • SRPS2A
    • SRTD6
    see all
  • Function
    Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death.
  • Tissue specificity
    High fetal expression in the brain and kidney.
  • Involvement in disease
    Short-rib thoracic dysplasia 6 with or without polydactyly
  • Sequence similarities
    Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
    Contains 1 protein kinase domain.
  • Cellular localization
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis (By similarity).
  • Information by UniProt

Images

  • 12.5% SDS-PAGE showing ab116949 at approximately 36.63kDa stained with Coomassie Blue.

References

ab116949 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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