The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Never in mitosis A-related kinase 1
Never in mitosis gene A-related kinase 1
NIMA (never in mitosis gene a)-related kinase 1
NIMA-related kinase 1
NimA-related protein kinase 1
Renal carcinoma antigen NY-REN-55
Serine/threonine-protein kinase Nek1
FunctionPhosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death.
Tissue specificityHigh fetal expression in the brain and kidney.
Involvement in diseaseShort-rib thoracic dysplasia 6 with or without polydactyly
Sequence similaritiesBelongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Contains 1 protein kinase domain.
Cellular localizationNucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis (By similarity).