This product is an active protein and may elicit a biological response in vivo, handle with caution.
Highly similar to cell cycle protein kinase CDC5/MSD2
Never in mitosis A-related kinase 6
NIMA (Never In Mitosis Gene A) Related Kinase 6
NimA related protein kinase 6
NimA-related protein kinase 6
Protein kinase SID6 1512
Protein kinase SID6-1512
Putative serine threonine protein kinase
Serine/threonine protein kinase Nek6
Serine/threonine-protein kinase Nek6
FunctionActivated during M phase. Required for chromosome segregation at metaphase-anaphase transition and therefore for mitotic progression. Inhibition of activity results in apoptosis. Phosphorylates KIF11 to promote mitotic spindle formation.
Tissue specificityUbiquitous, with highest expression in heart and skeletal muscle.
Sequence similaritiesBelongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Contains 1 protein kinase domain.