The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Peptidase inhibitor 12
Protease inhibitor 12
Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1
Serine or cysteine proteinase inhibitor clade I member 1
Serpin peptidase inhibitor clade I (neuroserpin) member 1
FunctionSerine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
Tissue specificityPredominantly expressed in the brain.
Involvement in diseaseDefects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) [MIM:604218]. FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin.
Sequence similaritiesBelongs to the serpin family.
Western blot - Anti-Neuroserpin antibody (ab16171)
Anti-Neuroserpin antibody (ab16171) at 1/2500 dilution + Recombinant Human Neuroserpin protein (ab63224) at 0.01 µg
Secondary Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution Developed using the ECL technique
Performed under reducing conditions.
Exposure time : 10 seconds
References for Recombinant Human Neuroserpin protein (ab63224)
This product has been referenced in:
Subhadra B et al. Neuroserpin up-regulation in the Alzheimer's disease brain is associated with elevated thyroid hormone receptor-ß1 and HuD expression. Neurochem Int63:476-81 (2013).
Read more (PubMed: 24036060) »