Recombinant Human Neurturin protein (ab9840)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      22 kDa

Specifications

Our Abpromise guarantee covers the use of ab9840 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Endotoxin level
    < 0.100 Eu/µg
  • Form
    Lyophilised
  • Additional notes
    Human Neurturin is fully biologically active when compared to standards. Human Neurturin at a concentration of 100ng/ml will support the survival of 65% of newborn rat sympathetic neurons.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    n/a

  • Reconstitution
    Reconstitute in water to a concentration of 0.1mg/ml

General Info

  • Alternative names
    • Neurturin
    • Neurturin precursor
    • NRTN
    • NRTN_HUMAN
    • NTN
    • prepro-neurturin
    see all
  • Function
    Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
  • Involvement in disease
    Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
  • Sequence similarities
    Belongs to the TGF-beta family. GDNF subfamily.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab9840 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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