The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityThe ED50 as determined by the ability to stimulate neurite growth in Chick E9 DRG cells is < 1.0 ng/ml.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. The protein is purified by proprietary chromatographic techniques.
>97% by SDS-PAGE and HPLC analyses
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionCentrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. The solution can be diluted into other aqueous buffers and stored at –20°C for future use.
Beta nerve growth factor
Beta-nerve growth factor
Nerve growth factor
Nerve growth factor (beta polypeptide)
Nerve growth factor beta
Nerve growth factor beta polypeptide
Nerve growth factor beta subunit
FunctionNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
Involvement in diseaseNeuropathy, hereditary sensory and autonomic, 5
Sequence similaritiesBelongs to the NGF-beta family.