Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP01138
    • SpeciesHuman
    • Molecular weight14 kDa
    • Amino acids1 to 119

Specifications

Our Abpromise guarantee covers the use of ab105059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe ED50 as determined by the ability to stimulate neurite growth in Chick E9 DRG cells is < 1.0 ng/ml.
  • Applications

    SDS-PAGE

    HPLC

  • Endotoxin level< 0.100 Eu/µg
  • Purity> 95 % SDS-PAGE.
    The protein is purified by proprietary chromatographic techniques. >97% by SDS-PAGE and HPLC analyses
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).

    Preservative: None

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionCentrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. The solution can be diluted into other aqueous buffers and stored at –20°C for future use.

General Info

  • Alternative names
    • Beta nerve growth factor
    • Beta NGF
    • Beta-nerve growth factor
    • Beta-NGF
    • HSAN5
    • MGC161426
    • MGC161428
    • Nerve growth factor
    • Nerve growth factor (beta polypeptide)
    • Nerve growth factor beta
    • Nerve growth factor beta polypeptide
    • Nerve growth factor beta subunit
    • NGF
    • NGF_HUMAN
    • NGFB
    • NID67
    see all
  • FunctionNerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
  • Involvement in diseaseNeuropathy, hereditary sensory and autonomic, 5
  • Sequence similaritiesBelongs to the NGF-beta family.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant human NGF protein (ab105059)

ab105059 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"