NF kappa B inhibitor interacting Ras like protein 2
NF-kappa-B inhibitor-interacting Ras-like protein 2
NFKB inhibitor interacting Ras like 2
NFKB inhibitor interacting Ras like protein 2
FunctionAtypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Tissue specificityWidely expressed.
Sequence similaritiesBelongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
DomainIn contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.