Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF
    • Amino acids
      28 to 225

Associated products

Specifications

Our Abpromise guarantee covers the use of ab50021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    > 95 % SDS-PAGE.
    Greater than 98% by SDS-PAGE and HPLC analyses.
  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Endotoxin level is less than 0.1 ng per µg (1EU/µg).

  • Reconstitution
    Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4oC for 1 week or -20oC for future use

General Info

  • Alternative names
    • B cell stimulating factor 3
    • B-cell-stimulating factor 3
    • BSF 3
    • BSF-3
    • BSF3
    • Cardiotrophin like cytokine
    • Cardiotrophin like cytokine factor 1
    • Cardiotrophin-like cytokine factor 1
    • CISS 2
    • CISS2
    • CLC
    • CLCF 1
    • Clcf1
    • CLCF1_HUMAN
    • Cold induced sweating syndrome 2
    • CRLF 1 associated cytokine like factor 1
    • CRLF1 associated cytokine like factor 1
    • Neurotrophin 1
    • Neurotrophin 1/B cell stimulating factor 3
    • Neurotrophin1
    • NNT 1
    • NNT-1
    • Novel neurotrophin 1
    • Novel neurotrophin-1
    • NR 6
    • NR6
    see all
  • Function
    Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.
  • Tissue specificity
    Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.
  • Involvement in disease
    Defects in CLCF1 are the cause of cold-induced sweating syndrome type 2 (CISS2) [MIM:610313]. Cold-induced sweating syndrome (CISS) is an autosomal recessive disorder characterized by profuse sweating induced by cool surroundings (temperatures of 7 to 18 degrees Celsius). Additional abnormalities include a high-arched palate, nasal voice, depressed nasal bridge, inability to fully extend the elbows and kyphoscoliosis.
  • Sequence similarities
    Belongs to the IL-6 superfamily.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab50021 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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