Recombinant Human Nodal protein (ab114307)

Overview

  • Product nameRecombinant Human Nodal protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionQ96S42
    • SpeciesHuman
    • SequenceRCEGECPNPVGEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSML YVDNGRVLLDHHKDMIVEECGC
    • Molecular weight34 kDa including tags
    • Amino acids275 to 346
    • TagsGST tag N-Terminus

Associated products

Specifications

Our Abpromise guarantee covers the use of ab114307 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05µg/µl
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • HTX5
    • MGC138230
    • Nodal
    • Nodal Growth Differentiation Factor
    • Nodal homolog
    • nodal homolog (mouse)
    • Nodal, Mouse, Homolog
    • NODAL_HUMAN
    see all
  • FunctionEssential for mesoderm formation and axial patterning during embryonic development.
  • Involvement in diseaseDefects in NODAL are the cause of visceral heterotaxy autosomal type 5 (HTX5) [MIM:270100]. A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy autosomal type 5 include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncuscommunis, and dextrocardia.
  • Sequence similaritiesBelongs to the TGF-beta family.
  • Cellular localizationSecreted.
  • Information by UniProt

Recombinant Human Nodal protein images

  • 12.5% SDS-PAGE image showing ab114307 Stained with Coomassie Blue.

References for Recombinant Human Nodal protein (ab114307)

ab114307 has not yet been referenced specifically in any publications.

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