Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human
    • Amino acids
      188 to 390

Specifications

Our Abpromise guarantee covers the use of ab90277 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS, 1mM EDTA

General Info

  • Alternative names
    • Maxp 1
    • MAXP1
    • MGC10823
    • MGC17344
    • New ras effector 1
    • NORE 1
    • NORE1A
    • NORE1B
    • Novel Ras effector 1
    • RAP1 Binding Protein
    • RAPL
    • Ras association (RalGDS/AF 6) domain family 5
    • Ras association (RalGDS/AF 6) domain family member 5
    • Ras association domain containing family protein 5
    • Ras association domain-containing protein 5
    • Ras effector like protein
    • RASF5_HUMAN
    • RASSF 3
    • RASSF 5
    • RASSF3
    • RASSF5
    • Regulator for cell adhesion and polarization enriched in lymphoid tissue
    • Regulator for cell adhesion and polarization enriched in lymphoid tissues
    • Tumor suppressor RASSF3
    see all
  • Function
    Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.
  • Tissue specificity
    Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
  • Sequence similarities
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 Ras-associating domain.
    Contains 1 SARAH domain.
  • Cellular localization
    Cytoplasm. Cytoplasm > cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
  • Information by UniProt

References

ab90277 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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