Recombinant Human NOX2/gp91phox protein (ab114183)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionP04839
    • SpeciesHuman
    • SequenceLFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYL AV
    • Molecular weight31 kDa including tags
    • Amino acids120 to 171

Specifications

Our Abpromise guarantee covers the use of ab114183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

    ELISA

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • AMCBX2
    • CGD
    • CGD91-phox
    • CY24B_HUMAN
    • CYBB
    • Cytochrome b 245, beta polypeptide
    • Cytochrome b(558) beta chain
    • Cytochrome b(558) subunit beta
    • Cytochrome b-245 heavy chain
    • Cytochrome b558 subunit beta
    • GP91 PHOX
    • gp91-1
    • gp91-phox
    • GP91PHOX
    • Heme-binding membrane glycoprotein gp91phox
    • NADPH oxidase 2
    • Neutrophil cytochrome b 91 kDa polypeptide
    • NOX2
    • p22 phagocyte B-cytochrome
    • P91 PHOX
    • p91-PHOX
    • Superoxide-generating NADPH oxidase heavy chain subunit
    see all
  • FunctionCritical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
  • Involvement in diseaseDefects in CYBB are a cause of chronic granulomatous disease X-linked (XCGD) [MIM:306400]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
  • Sequence similaritiesContains 1 FAD-binding FR-type domain.
    Contains 1 ferric oxidoreductase domain.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localizationMembrane.
  • Information by UniProt

Recombinant Human NOX2/gp91phox protein images

  • ab114183 on a 12.5% SDS-PAGE Stained with Coomassie Blue.

References for Recombinant Human NOX2/gp91phox protein (ab114183)

ab114183 has not yet been referenced specifically in any publications.

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Vielen Dank für Ihre Anfrage. Gegen die genannten NADPH-Oxidase-Komponenten haben wir folgende Antikörper bzw. Proteine in unserem Katalog: Click here (or use the following: http://www.abcam.com/index.html?datasheet=109366). Click here (or use the...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"