Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab59663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    Western blot

  • Form
    Lyophilised
  • Additional notes

    Freeze the reconstituted enzyme in one-use-size aliquots  at −20°C or −80°C while avoiding freeze/thaw cycles.

    This protein has been shown to activate quinone based anti-tumor agents in vivo.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C. Avoid freeze / thaw cycle. Please see notes section.

    Preservative: None
    Constituents: 8% PBS buffer salts, 2% Lactose

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute the contents of the vial with 0.1ml water.

General Info

  • Alternative names
    • Azoreductase
    • Cytochrome b 5 reductase
    • DHQU
    • DIA 4
    • DIA4
    • Diaphorase (NADH/NADPH)
    • Diaphorase (NADH/NADPH) (cytochrome b 5 reductase)
    • Diaphorase 4
    • Dioxin inducible 1
    • DT diaphorase
    • DT-diaphorase
    • DTD
    • Menadione reductase
    • NAD(P)H dehydrogenase [quinone] 1
    • NAD(P)H dehydrogenase quinone 1
    • NAD(P)H menadione oxidoreductase 1 dioxin inducible
    • NAD(P)H quinone dehydrogenase 1
    • NAD(P)H: menadione oxidoreductase 1 dioxin inducible 1
    • NAD(P)H:menadione oxidoreductase 1
    • NAD(P)H:Quinone acceptor oxidoreductase type 1
    • NAD(P)H:quinone oxidoreductase 1
    • NAD(P)H:quinone oxireductase
    • NMOR 1
    • NMOR I
    • NMOR1
    • NMORI
    • NQO 1
    • NQO1
    • NQO1_HUMAN
    • Phylloquinone reductase
    • QR 1
    • QR1
    • Quinone reductase 1
    see all
  • Function
    The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
  • Sequence similarities
    Belongs to the NAD(P)H dehydrogenase (quinone) family.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References

This product has been referenced in:
  • Xie W  et al. Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation. PLoS One 10:e0119738 (2015). ELISA . Read more (PubMed: 25780921) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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