Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMPTDHEE PCGPSHKSFC LNGGLCYVIP TIPSPFCRCV ENYTGARCEE VFLPGSSIQT KSNL
    • Molecular weight
      9 kDa including tags
    • Amino acids
      1 to 61
    • Tags
      His tag N-Terminus
    • Additional sequence information
      NCBI Accession No. NP_612640

Specifications

Our Abpromise guarantee covers the use of ab174432 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    >90% by SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • DKFZp779N0541
    • DKFZp779N1944
    • Heregulin 4
    • HRG4
    • Neuregulin 4
    • Neuregulin-4
    • NRG-4
    • NRG4
    • NRG4_HUMAN
    • pro-neuregulin-4, membrane-bound isoform
    • Pro-NRG4
    see all
  • Function
    Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
  • Sequence similarities
    Belongs to the neuregulin family.
    Contains 1 EGF-like domain.
  • Domain
    The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.
    ERBB receptor binding is elicited entirely by the EGF-like domain.
  • Post-translational
    modifications
    Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
    Extensive glycosylation precedes the proteolytic cleavage.
  • Cellular localization
    Secreted and Cell membrane. Does not seem to be active.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab174432 (3 μg).

References

ab174432 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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