Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ9GZY6
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MRCSRPGAKR SEKIYQQRSL REDQQSFTGS RTYSLVGQAW PGPLADMAPT RKDKLLQFYP SLEDPASSRY QNFSKGSRHG SEEAYIDPIA MEYYNWGRFS KPPEDDDANS YENVLICKQK TTETGAQQEG IGGLCRGDLS LSLALKTGPT SGLCPSASPE EDEESEDYQN SASIHQWRES RKVMGQLQRE ASPGPVGSPD EEDGEPDYVN GEVAATEA
    • Molecular weight26 kDa including tags
    • Amino acids27 to 243
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab95498 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0

General Info

  • Alternative names
    • HSPC046
    • LAB
    • LAT2
    • Linker for activation of B cells
    • Linker for activation of B-cells
    • Linker for activation of T cells family member 2
    • Linker for activation of T cells transmembrane adaptor 2
    • Linker for activation of T-cells family member 2
    • Membrane associated adapter molecule
    • Membrane-associated adapter molecule
    • Non T cell activation linker
    • Non-T-cell activation linker
    • NTAL_HUMAN
    • WBSCR 5
    • Wbscr15
    • Williams Beuren syndrome chromosome region 15
    • Williams Beuren syndrome chromosome region 5
    • Williams-Beuren syndrome chromosomal region 15 protein
    • Williams-Beuren syndrome chromosomal region 5 protein
    • WSCR5
    see all
  • FunctionInvolved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
  • Tissue specificityHighly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
  • Involvement in diseaseNote=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • Post-translational
    modifications
    Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
    May be polyubiquitinated.
  • Cellular localizationCell membrane. Present in lipid rafts.
  • Information by UniProt

Recombinant Human NTAL protein images

  • 15% SDS-PAGE analysis of 3µg ab95498.

References for Recombinant Human NTAL protein (ab95498)

ab95498 has not yet been referenced specifically in any publications.

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