Recombinant human Nuclear Receptor Corepressor NCoR protein (ab82239)

Overview

Description

  • NatureRecombinant
  • SourceBaculovirus
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab82239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityab82239 has been tested for deacetylation activity in vitro in the presence of HDAC3.
  • Applications

    Functional Studies

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab82239 is greater than 95% homogeneous based on SDS-PAGE gel analysis, purified by an affinity column in combination with FPLC chromatography.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • hN CoR
    • hNCoR
    • KIAA1047
    • N CoR
    • N Cor/SMRT corepressor Rip13
    • N CoR1
    • N-CoR
    • N-CoR1
    • NCoR
    • NCOR 1
    • Ncor1
    • NCOR1_HUMAN
    • Nuclear receptor co repressor 1
    • Nuclear receptor corepressor 1
    • Retinoid X receptor interacting protein 13
    • RIP13
    • Rxrip13
    • thyroid hormone and retinoic acid receptor associated corepressor 1
    • TRAC 1
    • TRAC1
    see all
  • FunctionMediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
  • Sequence similaritiesBelongs to the N-CoR nuclear receptor corepressors family.
    Contains 2 SANT domains.
  • DomainThe N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
    The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.
  • Post-translational
    modifications
    Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Recombinant human Nuclear Receptor Corepressor NCoR protein (ab82239)

This product has been referenced in:
  • Isaacs JT  et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res 73:1386-99 (2013). Read more (PubMed: 23149916) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"