Diphosphoinositol polyphosphate phosphohydrolase type 3 alpha
DIPP 3 alpha
Nucleoside diphosphate linked moiety X motif 10
Nucleoside diphosphate-linked moiety X motif 10
Nudix (nucleoside diphosphate linked moiety X) type motif 10
Nudix motif 10
Nudix type motif 10
P6-hexaphosphate hydrolase 3-alpha
FunctionCleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Tissue specificityMainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed.
Sequence similaritiesBelongs to the Nudix hydrolase family. DIPP subfamily. Contains 1 nudix hydrolase domain.