Nudix (nucleoside diphosphate linked moiety X) type motif 16
Nudix motif 16
U8 snoRNA-binding protein H29K
U8 snoRNA-decapping enzyme
FunctionRNA-decapping enzyme that binds specifically to U8 snoRNA. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and m227G caps from U8 snoRNA. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species (in vitro).
Sequence similaritiesBelongs to the Nudix hydrolase family. Contains 1 nudix hydrolase domain.
Cellular localizationNucleus > nucleolus. Nucleus > nucleoplasm. Predominantly localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm.