Cleavage and polyadenylation specific factor 5 25 kD subunit
Cleavage and polyadenylation specific factor 5 25 kDa
Cleavage and polyadenylation specificity factor 25 kDa subunit
Cleavage and polyadenylation specificity factor subunit 5
Cleavage factor Im complex 25 kDa subunit
CPSF 25 kDa subunit
Nucleoside diphosphate linked moiety X motif 21
Nucleoside diphosphate-linked moiety X motif 21
Nudix (nucleoside diphosphate linked moiety X) type motif 21
Nudix motif 21
Pre mRNA cleavage factor Im (25kD)
Pre mRNA cleavage factor Im 25 kDa subunit
Pre mRNA cleavage factor Im 25kD subunit
Pre-mRNA cleavage factor Im 25 kDa subunit
FunctionComponent of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.
Sequence similaritiesBelongs to the Nudix hydrolase family. CPSF5 subfamily. Contains 1 nudix hydrolase domain.
Post-translational modificationsAcetylated mainly by p300/CBP, recruited to the complex by CPSF6. Acetylation decreases interaction with PAPAO. Deacetylated by the class I/II HDACs, HDAC1, HDAC3 and HDAC10, and by the class III HDACs, SIRT1 AND SIRT2.
Cellular localizationNucleus. In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.