Overview

  • Product name
    Recombinant Human NUDT3 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR
    • Molecular weight
      22 kDa including tags
    • Amino acids
      1 to 172
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab103915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 95 % SDS-PAGE.
    Purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 5mM DTT, 200mM Sodium chloride, 20mM Tris HCl, pH 8

General Info

  • Alternative names
    • 5''''-P1
    • Diadenosine 5' 5''' P1 P6 hexaphosphate hydrolase 1
    • Diadenosine 5''
    • Diphosphoinositol polyphosphate phosphohydrolase
    • Diphosphoinositol polyphosphate phosphohydrolase 1
    • DIPP
    • DIPP 1
    • DIPP-1
    • DIPP1
    • Nucleoside diphosphate linked moiety X motif 3
    • Nucleoside diphosphate-linked moiety X motif 3
    • Nudix (nucleoside diphosphate linked moiety X) type motif 3
    • Nudix motif 3
    • Nudix type motif 3
    • NUDT 3
    • Nudt3
    • NUDT3_HUMAN
    • P6-hexaphosphate hydrolase 1
    see all
  • Function
    Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
  • Tissue specificity
    Widely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
  • Sequence similarities
    Belongs to the Nudix hydrolase family. DIPP subfamily.
    Contains 1 nudix hydrolase domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Recombinant Human NUDT3 protein images

  • 15% SDS-PAGE analysis of ab103915 (3 µg).

References for Recombinant Human NUDT3 protein (ab103915)

ab103915 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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