Overview

  • Product nameRecombinant Human NUDT3 protein
  • Protein lengthFull length protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionO95989
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MMKLKSNQTR TYDGDGYKKR AACLCFRSES EEEVLLVSSS RHPDRWIVPG GGMEPEEEPS VAAVREVCEE AGVKGTLGRL VGIFENQERK HRTYVYVLIV TEVLEDWEDS VNIGRKREWF KIEDAIKVLQ YHKPVQASYF ETLRQGYSAN NGTPVVATTY SVSAQSSMSG IR
    • Molecular weight22 kDa including tags
    • Amino acids1 to 172
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab103915 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity> 95 % SDS-PAGE.
    Purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20mM Tris pH 7.5, 2mM EDTA.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 5mM DTT, 200mM Sodium chloride, 20mM Tris HCl, pH 8

General Info

  • Alternative names
    • 5''''-P1
    • Diadenosine 5' 5''' P1 P6 hexaphosphate hydrolase 1
    • Diadenosine 5''
    • Diphosphoinositol polyphosphate phosphohydrolase
    • Diphosphoinositol polyphosphate phosphohydrolase 1
    • DIPP
    • DIPP 1
    • DIPP-1
    • DIPP1
    • Nucleoside diphosphate linked moiety X motif 3
    • Nucleoside diphosphate-linked moiety X motif 3
    • Nudix (nucleoside diphosphate linked moiety X) type motif 3
    • Nudix motif 3
    • Nudix type motif 3
    • NUDT 3
    • Nudt3
    • NUDT3_HUMAN
    • P6-hexaphosphate hydrolase 1
    see all
  • FunctionCleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
  • Tissue specificityWidely expressed. Expressed at higher level in brain, heart, pancreas and liver. Also expressed in placenta, lung and kidney.
  • Sequence similaritiesBelongs to the Nudix hydrolase family. DIPP subfamily.
    Contains 1 nudix hydrolase domain.
  • Cellular localizationCytoplasm.
  • Information by UniProt

Recombinant Human NUDT3 protein images

  • 15% SDS-PAGE analysis of ab103915 (3 µg).

References for Recombinant Human NUDT3 protein (ab103915)

ab103915 has not yet been referenced specifically in any publications.

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