Overview

  • Product name
    Recombinant Human Nurr1 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      GFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPP GTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFP
    • Molecular weight
      37 kDa including tags
    • Amino acids
      71 to 170

Specifications

Our Abpromise guarantee covers the use of ab114341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • HZF 3
    • HZF3
    • Immediate-early response protein NOT
    • Intermediate early receptor protein
    • NGFI B/nur77 beta type transcription factor homolog
    • NOT
    • Nr4a2
    • NR4A2_HUMAN
    • nuclear receptor of T cells
    • nuclear receptor related 1
    • Nuclear receptor subfamily 4 group A member 2
    • Nur related protein 1 homolog
    • nur related protein-1, human homolog of
    • Nurr 1
    • Orphan nuclear receptor NR4A2
    • Orphan nuclear receptor NURR1
    • RNR 1
    • RNR1
    • T cell nuclear receptor NOT
    • T-cell nuclear receptor NOT
    • TINUR
    • Transcriptionally inducible nuclear receptor
    • Transcriptionally inducible nuclear receptor related
    • Transcriptionally inducible nuclear receptor related 1
    • Transcriptionally-inducible nuclear receptor
    see all
  • Function
    Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.
  • Tissue specificity
    Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR4 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Developmental stage
    Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • ab114341 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

References

ab114341 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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