Solute carrier organic anion transporter family member 1B1
FunctionMediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver.
Tissue specificityHighly expressed in liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
Sequence similaritiesBelongs to the organo anion transporter (TC 2.A.60) family. Contains 1 Kazal-like domain.
Cellular localizationBasolateral cell membrane. Detected in basolateral membranes of hepatocytes.