Oligonucleotide/oligosaccharide binding fold containing protein 2A
Oligonucleotide/oligosaccharide-binding fold-containing protein 2A
Sensor of single strand DNA complex subunit B2
Sensor of single-strand DNA complex subunit B2
Sensor of ssDNA subunit B2
Single stranded DNA binding protein 2
Single-stranded DNA-binding protein 2
SOSS complex subunit B2
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Belongs to the SOSS-B family. SOSS-B2 subfamily. Contains 1 OB DNA-binding domain.
Nucleus. Localizes to nuclear foci following DNA damage.