Recombinant Human OBFC2A protein (ab171488)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMNRVNDP LIFIRDIKPG LKNLNVVFIV LEIGRVTKTK DGHEVRSCKV ADKTGSITIS VWDEIGGLIQ PGDIIRLTRG YASMWKGCLT LYTGRGGELQ KIGEFCMVYS EVPNFSEPNP DYRGQQNKGA QSEQKNNSMN SNMGTGTFGP VGNGVHTGPE SREHQFSHAG RSNGRGLINP QLQGTASNQT VMTTISNGRD PRRAFKR
    • Molecular weight
      25 kDa including tags
    • Amino acids
      1 to 204
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab171488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    >95% by SDS-PAGE .
    ab171488 was purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.03% DTT, 0.32% Tris HCl, 50% Glycerol, 1.17% Sodium chloride

General Info

  • Alternative names
    • FLJ13624
    • FLJ22833
    • hSSB2
    • MGC111163
    • Nabp1
    • Nucleic acid-binding protein 1
    • OBFC2A
    • Oligonucleotide/oligosaccharide binding fold containing 2A
    • Oligonucleotide/oligosaccharide binding fold containing protein 2A
    • Oligonucleotide/oligosaccharide-binding fold-containing protein 2A
    • Sensor of single strand DNA complex subunit B2
    • Sensor of single-strand DNA complex subunit B2
    • Sensor of ssDNA subunit B2
    • Single stranded DNA binding protein 2
    • Single-stranded DNA-binding protein 2
    • SOSB2_HUMAN
    • SOSS B2
    • SOSS complex subunit B2
    • SOSS-B2
    • SSB2
    see all
  • Function
    Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
  • Sequence similarities
    Belongs to the SOSS-B family. SOSS-B2 subfamily.
    Contains 1 OB DNA-binding domain.
  • Cellular localization
    Nucleus. Localizes to nuclear foci following DNA damage.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3µg ab171488.

References

ab171488 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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