Oligonucleotide/oligosaccharide binding fold containing protein 2B
Sensor of single strand DNA complex subunit B1
Sensor of ssDNA subunit B1
Single stranded DNA binding protein 1
SOSS complex subunit B1
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage.
OBFC2B plays an important role in DNA damage response. It influences diverse endpoints in the cellular DNA damage response, including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. It associates with DNA lesions, and enables the efficient activation of ATM and consequent phosphorylation of downstream proteins.
Nuclear. Localizes to nuclear foci following DNA damage.
ab163963 on a 12.5% SDS-PAGE stained with Coomassie Blue.
has not yet been referenced specifically in any publications.
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