Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionO43929
    • SpeciesHuman
    • SequenceMSSRKSKSNSLIHTECLSQVQRILRERFCRQSPHSNLFGVQVQYKHLSEL LKRTALHGESNSVLIIGPRGSGKTMLISHALKELMEIEEVSENVLQVHLN GLLQINDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALKKGDRTS SCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILE LLEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSLPAEFPDKVFAEK
    • Molecular weight53 kDa including tags
    • Amino acids1 to 248

Specifications

Our Abpromise guarantee covers the use of ab114619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

General Info

  • Alternative names
    • Origin recognition complex, subunit 4, S. cerevisiae, homolog of
    • FLJ46668
    • HSORC4
    • ORC 4
    • ORC 4L
    • ORC 4P
    • ORC4
    • ORC4_HUMAN
    • ORC4L
    • ORC4L protein
    • ORC4P
    • Origin recognition complex subunit 4
    • Origin recognition complex subunit 4 (yeast homolog) like
    • Origin recognition complex subunit 4 like
    • Origin recognition complex subunit 4 like (yeast)
    • origin recognition complex, subunit 4 homolog
    • Origin recognition complex, subunit 4, S. cerevisiae, homolog-like
    see all
  • FunctionComponent of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
  • Involvement in diseaseDefects in ORC4 are the cause of Meier-Gorlin syndrome type 2 (MGORS2) [MIM:613800]. MGORS2 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
  • Sequence similaritiesBelongs to the ORC4 family.
  • Cellular localizationNucleus.
  • Information by UniProt

Recombinant Human ORC4L protein images

  • ab114619 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

References for Recombinant Human ORC4L protein (ab114619)

ab114619 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114619.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"