OTU domain containing ubiquitin aldehyde binding protein 2
OTU domain, ubiquitin aldehyde binding 2
OTU domain-containing ubiquitin aldehyde-binding protein 2
Ubiquitin specific processing protease OTUB2
Ubiquitin specific protease otubain 2
Ubiquitin thioesterase OTUB2
Ubiquitin-specific-processing protease OTUB2
FunctionHydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
Tissue specificityWidely expressed. Expressed at higher level in brain.
Sequence similaritiesBelongs to the peptidase C65 family. Contains 1 OTU domain.