p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Cell Membrane, Cytoplasmic and Nuclear
Functional Studies - p35 + p25 protein (Tagged) (ab60761)
Sample Kinase Activity Plot.
SDS-PAGE - p35 + p25 protein (Tagged) (ab60761)
ab60761 on SDS-PAGE, p35 MW 59kDa and p25 49kDa.
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