The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological Activity: Inhibits rat NGF-mediated activation of rat PC12 cells.
< 0.100 Eu/µg
>95% by SDS-PAGE .
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C.
Constituent: 99% PBS
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute in 50µl sterile water to a concentration of 1 mg/ml. Further dilutions can be made with medium containing 5% fetal calf serum.
After reconstitution, it is recommended to make appropriate aliquots and to store them at -20°C.
Low affinity nerve growth factor receptor
Low affinity neurotrophin receptor p75NTR
Low-affinity nerve growth factor receptor
Nerve growth factor receptor
Nerve growth factor receptor TNFR superfamily member 16
p75 Neurotrophin receptor
TNFR Superfamily Member 16
Tumor necrosis factor receptor superfamily member 16
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Contains 1 death domain. Contains 4 TNFR-Cys repeats.
Death domain is responsible for interaction with RANBP9. The extracellular domain is responsible for interaction with NTRK1.
N- and O-glycosylated. O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. Phosphorylated on serine residues.