Pituitary adenylate cyclase activating polypeptide type I receptor precursor
Pituitary adenylate cyclase-activating polypeptide type I receptor
FunctionThis is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
Tissue specificityMost abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
Sequence similaritiesBelongs to the G-protein coupled receptor 2 family.