Phospholipase A2, group VII (platelet activating factor acetylhydrolase, plasma)
Platelet activating factor acetylhydrolase
Platelet activating factor acetylhydrolase 2
Platelet-activating factor acetylhydrolase
FunctionModulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Involvement in diseasePlatelet-activating factor acetylhydrolase deficiency Asthma Atopic hypersensitivity
Sequence similaritiesBelongs to the AB hydrolase superfamily. Lipase family.